HCID 178432711, compound → 4-Cyclopropyl-5-(5-methoxy-1H-1,2,4-triazol-3-yl)-2-methylbenzoic acid

HRID 1487988Notes

Reaction equation

HRID 1487988 reaction equation
CC1NC(C2C=C(C=CC=2C)C(O)=O)=C(C)N=1.[CH:18]1([C:21]2[C:30]([C:31]3[NH:35][C:34]([O:36][CH3:37])=[N:33][N:32]=3)=[CH:29][C:24]([C:25]([O:27]C)=[O:26])=[C:23]([CH3:38])[CH:22]=2)[CH2:20][CH2:19]1.CC1NC(C2C=C(C=CC=2C)C(OC)=O)=C(C)N=1>>[CH:18]1([C:21]2[C:30]([C:31]3[NH:35][C:34]([O:36][CH3:37])=[N:33][N:32]=3)=[CH:29][C:24]([C:25]([OH:27])=[O:26])=[C:23]([CH3:38])[CH:22]=2)[CH2:19][CH2:20]1

Participants

4

Reactant 3

HCID 178432711HCID 178432711, compoundHCID 178497405HCID 178497405, compound2×HCID 178497719HCID 178497719, compound

Product 1

HCID 1784943084-Cyclopropyl-5-(5-methoxy-1H-1,2,4-triazol-3-yl)-2-methylbenzoic acid

Procedure

The title compound was prepared using standard chemical manipulations and procedures similar to those used for the preparation of compound 5.7, except methyl 4-cyclopropyl-5-(5-methoxy-4H-1,2,4-triazol-3-yl)-2-methylbenzoate (compound 91.5) was used in place of methyl 3-(2,4-dimethyl-1H-imidazol-5-yl)-4-methylbenzoate (compound 5.6). m/z (ES+) 274 (M+H)+.

Sources & evidence

ORD record
ord-4c28ee423f024851aa709d58cad28e95
Source dataset
uspto-grants-2016_08
Patent number
US09428502B2

Reaction notes

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