4-(Piperidin-4-yl)benzonitrile--hydrogen chloride (1/1) → HCID 178433961, compound

HRID 1487993Notes

Reaction equation

HRID 1487993 reaction equation
[C:1]([C:3]1[C:4]([F:14])=[CH:5][C:6]([CH3:13])=[C:7]([CH:12]=1)[C:8](OC)=[O:9])#[N:2].[C:15]([C:17]1C(C2CCC2)=CC(C)=C(C=1)C(OC)=O)#[N:16].Cl.[NH:33]1[CH2:38][CH2:37][CH:36]([C:39]2[CH:46]=[CH:45][C:42]([C:43]#[N:44])=[CH:41][CH:40]=2)[CH2:35][CH2:34]1.Cl.[NH:48]1CCC(C2C=CC3N(C=CN=3)C=2)CC1>>[F:14][C:4]1[C:3]([C:1]2[NH:2][C:15]([CH3:17])=[N:16][N:48]=2)=[CH:12][C:7]([C:8]([N:33]2[CH2:38][CH2:37][CH:36]([C:39]3[CH:46]=[CH:45][C:42]([C:43]#[N:44])=[CH:41][CH:40]=3)[CH2:35][CH2:34]2)=[O:9])=[C:6]([CH3:13])[CH:5]=1

Participants

5

Reactant 4

HCID 193916184-(Piperidin-4-yl)benzonitrile--hydrogen chloride (1/1)2×HCID 68288299Methyl 5-cyano-4-cyclobutyl-2-methylbenzoateHCID 90021743Methyl 5-cyano-4-fluoro-2-methylbenzoate2×HCID 900303826-(Piperidin-4-yl)imidazo[1,2-a]pyridine hydrochloride

Product 1

HCID 178433961HCID 178433961, compound

Procedure

The title compound was prepared using standard chemical manipulations and procedures similar to those used for the preparation of compound 78, except methyl 5-cyano-4-fluoro-2-methylbenzoate (compound 101.3) was used in place of methyl 5-cyano-4-cyclobutyl-2-methylbenzoate (compound 6.4) and 4-(piperidin-4-yl)benzonitrile hydrochloride (compound 1.2) was used in place of 6-(piperidin-4-yl)imidazo[1,2-a]pyridine hydrochloride (compound 78.5).

Sources & evidence

ORD record
ord-db9d63a260ac4f18883ef33fa9a2a183
Source dataset
uspto-grants-2016_08
Patent number
US09428502B2

Reaction notes

Loading…