Methyl 3-(2-(methoxymethyl)-1H-imidazol-5-yl)-4-methylbenzoate → HCID 178425887, compound

HRID 1488009Notes

Reaction equation

HRID 1488009 reaction equation
[Cl:1][C:2]1[N:3]=[C:4]([CH2:18]OC)[NH:5][C:6]=1[C:7]1[CH:8]=[C:9]([CH:14]=[CH:15][C:16]=1[CH3:17])[C:10]([O:12]C)=[O:11].[N:21]1([CH2:25]CC2NC(C3C=C(C=CC=3C)C(OC)=O)=CN=2)[CH2:24][CH2:23][CH2:22]1.COCC1NC(C2C=C(C=CC=2C)C(OC)=O)=CN=1>>[N:21]1([CH2:25][CH2:18][C:4]2[NH:5][C:6]([C:7]3[CH:8]=[C:9]([CH:14]=[CH:15][C:16]=3[CH3:17])[C:10]([OH:12])=[O:11])=[C:2]([Cl:1])[N:3]=2)[CH2:24][CH2:23][CH2:22]1

Participants

4

Reactant 3

HCID 90030068Methyl 3-(2-(methoxymethyl)-1H-imidazol-5-yl)-4-methylbenzoateHCID 90030616Methyl 3-(2-(2-(azetidin-1-yl)ethyl)-1H-imidazol-5-yl)-4-methylbenzoate2×HCID 178494680HCID 178494680, compound

Product 1

HCID 178425887HCID 178425887, compound

Procedure

The title compound was prepared using standard chemical manipulations and procedures similar to those used for the preparation of compounds 27.4 and 27.5, except methyl 3-(2-(2-(azetidin-1-yl)ethyl)-1H-imidazol-5-yl)-4-methylbenzoate (compound 157.2) was used in place of methyl 3-(2-(methoxymethyl)-1H-imidazol-5-yl)-4-methylbenzoate (compound 27.3).

Sources & evidence

ORD record
ord-002c381228d04df6b01e42249cab7c72
Source dataset
uspto-grants-2016_08
Patent number
US09428502B2

Reaction notes

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