HCID 178432600, compound → HCID 178425884, compound

HRID 1488022Notes

Reaction equation

HRID 1488022 reaction equation
[CH3:1][C:2]1[NH:3][C:4]([C:8]2[CH:9]=[C:10]([CH:14]=[CH:15][C:16]=2[CH3:17])[C:11]([OH:13])=[O:12])=[C:5]([CH3:7])[N:6]=1.IC1NC(C2[CH2:29][CH2:28][O:27][CH2:26][CH2:25]2)=NC=1C.IC1NC(C)=NC=1C>>[CH3:17][C:16]1[CH:15]=[CH:14][C:10]([C:11]([OH:13])=[O:12])=[CH:9][C:8]=1[C:4]1[NH:3][C:2]([CH:1]2[CH2:29][CH2:28][O:27][CH2:26][CH2:25]2)=[N:6][C:5]=1[CH3:7]

Participants

4

Reactant 3

HCID 178432600HCID 178432600, compound2×HCID 178432711HCID 178432711, compoundHCID 178432771HCID 178432771, compound

Product 1

HCID 178425884HCID 178425884, compound

Procedure

The title compound was prepared using standard chemical manipulations and procedures similar to those used for the preparation of compound 5.7, except 5-iodo-4-methyl-2-(tetrahydro-2H-pyran-4-yl)-1H-imidazole (compound 164.1) was used in place of 5-iodo-2,4-dimethyl-1H-imidazole (compound 5.5).

Sources & evidence

ORD record
ord-9754cb3ed6d94fcd8e02caf2e8712323
Source dataset
uspto-grants-2016_08
Patent number
US09428502B2

Reaction notes

Loading…