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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1488024Generated: October 28, 2026

4-(Azetidin-3-yl)benzonitrile hydrochloride → HCID 178425808, compound

https://huagongshe.com/reaction/1488024

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Azetidin-3-yl)benzonitrile hydrochlorideHCID 55254991—
Reactant4-(3-Fluoroazetidin-3-yl)benzonitrile hydrochlorideHCID 90021334—
Reactant2,4-Dimethyl-5-(4-methyl-2-(tetrahydro-2H-pyran-4-yl)-1H-imidazol-5-yl)benzoic acidHCID 90029976—
ReactantHCID 178425884HCID 178425884—
ProductHCID 178425808HCID 178425808—

Reaction Steps

The title compound was prepared using standard chemical manipulations and procedures similar to those used for the preparation of compound 164, except 4-methyl-3-(4-methyl-2-(tetrahydro-2H-pyran-4-yl)-1H-imidazol-5-yl)benzoic acid (compound 168.1) was used in place of 2,4-dimethyl-5-(4-methyl-2-(tetrahydro-2H-pyran-4-yl)-1H-imidazol-5-yl)benzoic acid (compound 164.2) and 4-(3-fluoroazetidin-3-yl)benzonitrile hydrochloride (compound 43.4) was used in place of 4-(azetidin-3-yl)benzonitrile hydrochloride (compound 5.2). m/z (ES+) 459 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09428502B2
Source datasetuspto-grants-2016_08
ORD IDord-6139fb7697a341b08b294242dde1f933
Source noteuspto-grants-2016_08