HCID 178432594, compound → HCID 178425881, compound

HRID 1488046Notes

Reaction equation

HRID 1488046 reaction equation
[CH3:1][C:2]1[NH:3][C:4]([C:8]2[CH:9]=[C:10]([CH:14]=[CH:15][C:16]=2[CH3:17])[C:11]([OH:13])=[O:12])=[C:5]([CH3:7])[N:6]=1.IC1NC(C2[CH2:29][CH2:28][N:27]([C:30]([O:32][C:33]([CH3:36])([CH3:35])[CH3:34])=[O:31])[CH2:26][CH2:25]2)=NC=1C.IC1NC(C)=NC=1C>>[C:33]([O:32][C:30]([N:27]1[CH2:28][CH2:29][CH:1]([C:2]2[NH:3][C:4]([C:8]3[CH:9]=[C:10]([CH:14]=[CH:15][C:16]=3[CH3:17])[C:11]([OH:13])=[O:12])=[C:5]([CH3:7])[N:6]=2)[CH2:25][CH2:26]1)=[O:31])([CH3:36])([CH3:35])[CH3:34]

Participants

4

Reactant 3

HCID 178432594HCID 178432594, compound2×HCID 178432711HCID 178432711, compoundHCID 178432771HCID 178432771, compound

Product 1

HCID 178425881HCID 178425881, compound

Procedure

The title compound was prepared using standard chemical manipulations and procedures similar to those used for the preparation of compound 5.7, except tert-butyl 4-(5-iodo-4-methyl-1H-imidazol-2-yl)piperidine-1-carboxylate (compound 182.1) was used in place of 5-iodo-2,4-dimethyl-1H-imidazole (compound 5.5).

Sources & evidence

ORD record
ord-d4417ff73b0f46d9a71c0aeb7e8e6b8b
Source dataset
uspto-grants-2016_08
Patent number
US09428502B2

Reaction notes

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