HCID 90029906, compound → HCID 178486371, compound

HRID 1488072Notes

Reaction equation

HRID 1488072 reaction equation
[OH:1][C:2]1([C:6]2[NH:7][C:8]([C:12]3[CH:13]=[C:14]([CH:29]=[CH:30][C:31]=3[CH3:32])[C:15]([N:17]3[CH2:20][CH:19]([C:21]4[CH:28]=[CH:27][C:24]([C:25]#[N:26])=[CH:23][CH:22]=4)[CH2:18]3)=[O:16])=[C:9]([CH3:11])[N:10]=2)[CH2:5][O:4][CH2:3]1.I[C:34]1N(COCC[Si](C)(C)C)C(C2(OC)COC2)=NC=1C.IC1N(COCC[Si](C)(C)C)C(C2(O)COC2)=NC=1C>>[CH3:34][O:1][C:2]1([C:6]2[NH:7][C:8]([C:12]3[CH:13]=[C:14]([CH:29]=[CH:30][C:31]=3[CH3:32])[C:15]([N:17]3[CH2:18][CH:19]([C:21]4[CH:28]=[CH:27][C:24]([C:25]#[N:26])=[CH:23][CH:22]=4)[CH2:20]3)=[O:16])=[C:9]([CH3:11])[N:10]=2)[CH2:3][O:4][CH2:5]1

Participants

4

Reactant 3

HCID 90029906HCID 90029906, compound2×HCID 90029991HCID 90029991, compoundHCID 178425793HCID 178425793, compound

Product 1

HCID 178486371HCID 178486371, compound

Procedure

The title compound was prepared using standard chemical manipulations and procedures similar to those used for the preparation of compound 192, except 5-iodo-2-(3-methoxyoxetan-3-yl)-4-methyl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole (compound 194.1) was used in place of 3-(5-iodo-4-methyl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)oxetan-3-ol (compound 192.3). m/z (ES+) 443 (M+H)+.

Sources & evidence

ORD record
ord-e740b41d1dc54301bf874f01f55a330b
Source dataset
uspto-grants-2016_08
Patent number
US09428502B2

Reaction notes

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