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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1488077Generated: October 30, 2026

4-(Piperidin-4-yl)benzonitrile--hydrogen chloride (1/1) → HCID 178425796, compound

https://huagongshe.com/reaction/1488077

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Piperidin-4-yl)benzonitrile--hydrogen chloride (1/1)HCID 19391618—
Reactant4-(Azetidin-3-yl)benzonitrile hydrochlorideHCID 55254991—
ReactantHCID 178497363HCID 178497363—
ReactantHCID 178497723HCID 178497723—
SolventEthyl AcetateHCID 8857—
ProductHCID 178425796HCID 178425796—

Reaction Steps

The title compound was prepared using standard chemical manipulations and procedures similar to those used for the preparation of compound 1, except methyl 4-methyl-3-(4-methyl-2-(pyrrolidin-1-yl)-1H-imidazol-5-yl)benzoate (compound 197.3) was used in place of methyl 5-(2,4-dimethyl-1H-imidazol-5-yl)-2,4-dimethylbenzoate (compound 1.7) and 4-(azetidin-3-yl)benzonitrile hydrochloride (compound 5.2) was used in place of 4-(piperidin-4-yl)benzonitrile hydrochloride (compound 1.2). m/z (ES+) 426 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09428502B2
Source datasetuspto-grants-2016_08
ORD IDord-72110a1c4dc945578559086c82962951
Source noteuspto-grants-2016_08