5-Methoxycarbonyl-2-methylphenylboronic acid pinacol ester → HCID 178497718, compound

HRID 1488079Notes

Reaction equation

HRID 1488079 reaction equation
[OH:1][CH:2]([C:4]1[NH:5][C:6]([C:10]2[C:11]([CH3:21])=[CH:12][C:13](C)=[C:14]([CH:19]=2)[C:15]([O:17][CH3:18])=[O:16])=[C:7]([CH3:9])[N:8]=1)[CH3:3].CC1C=CC(C(OC)=O)=CC=1B1OC(C)(C)C(C)(C)O1.CC1C=C(C)C(B2OC(C)(C)C(C)(C)O2)=CC=1C(OC)=O>>[OH:1][CH:2]([C:4]1[NH:5][C:6]([C:10]2[CH:19]=[C:14]([CH:13]=[CH:12][C:11]=2[CH3:21])[C:15]([O:17][CH3:18])=[O:16])=[C:7]([CH3:9])[N:8]=1)[CH3:3]

Participants

4

Reactant 3

HCID 532171365-Methoxycarbonyl-2-methylphenylboronic acid pinacol ester2×HCID 59224686Methyl 2,4-dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoateHCID 178497359HCID 178497359, compound

Product 1

HCID 178497718HCID 178497718, compound

Procedure

The title compound was prepared using standard chemical manipulations and procedures similar to those used for the preparation of compound 198.3, except methyl 4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (compound 5.4) was used in place of methyl 2,4-dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (compound 160.1).

Sources & evidence

ORD record
ord-80d81e3b4ead49e3a1a24f50c0239f4e
Source dataset
uspto-grants-2016_08
Patent number
US09428502B2

Reaction notes

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