Methyl 3-(4-cyano-2-(3-methyloxetan-3-yl)-1H-imidazol-5-yl)-4-methylbenzoate → 3-(4-Cyano-2-(3-methyloxetan-3-yl)-1H-imidazol-5-yl)-4-methylbenzoic acid

HRID 1488084Notes

Reaction equation

HRID 1488084 reaction equation
CC1NC(C2C=C(C=CC=2C)C(O)=O)=C(C)N=1.[C:18]([C:20]1[N:21]=[C:22]([C:36]2([CH3:40])[CH2:39][O:38][CH2:37]2)[NH:23][C:24]=1[C:25]1[CH:26]=[C:27]([CH:32]=[CH:33][C:34]=1[CH3:35])[C:28]([O:30]C)=[O:29])#[N:19].CC1NC(C2C=C(C=CC=2C)C(OC)=O)=C(C)N=1>>[C:18]([C:20]1[N:21]=[C:22]([C:36]2([CH3:40])[CH2:39][O:38][CH2:37]2)[NH:23][C:24]=1[C:25]1[CH:26]=[C:27]([CH:32]=[CH:33][C:34]=1[CH3:35])[C:28]([OH:30])=[O:29])#[N:19]

Participants

4

Reactant 3

HCID 90030232Methyl 3-(4-cyano-2-(3-methyloxetan-3-yl)-1H-imidazol-5-yl)-4-methylbenzoate2×HCID 178432711HCID 178432711, compoundHCID 178497719HCID 178497719, compound

Product 1

HCID 900298953-(4-Cyano-2-(3-methyloxetan-3-yl)-1H-imidazol-5-yl)-4-methylbenzoic acid

Procedure

The title compound was prepared using standard chemical manipulations and procedures similar to those used for the preparation of compound 5.7, except methyl 3-(4-cyano-2-(3-methyloxetan-3-yl)-1H-imidazol-5-yl)-4-methylbenzoate (compound 202.4) was used in place of methyl 3-(2,4-dimethyl-1H-imidazol-5-yl)-4-methylbenzoate (compound 5.6). m/z (ES+) 298 (M+H)+.

Sources & evidence

ORD record
ord-7b0d34e83da247bf82bb3e7f0ba99038
Source dataset
uspto-grants-2016_08
Patent number
US09428502B2

Reaction notes

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