反应详情

Into a 50-mL round-bottom flask, was placed a solution of 2-methyl-4-(trifluoromethyl)-1H-imidazole (compound 16.2, 1.72 g, 11.46 mmol) in CH3CN (25 mL). NIS (3.87 g, 17.20 mmol) was added to the reaction. The reaction mixture was stirred overnight at 85. The reaction mixture diluted with 50 mL of H2O and extracted with 3×30 mL of ethyl acetate. The combined organic layers were washed with 2×20 mL of Na2S2O3(sat.) and 2×20 mL of brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure. This resulted in 4.32 g (crude) of the title compound as a brown oil.

1. customInto a 50-mL round-bottom flask, was placed
2. extractionextracted with 3×30 mL of ethyl acetate
3. washThe combined organic layers were washed with 2×20 mL of Na2S2O3(sat.) and 2×20 mL of brine
4. dry with materialdried over anhydrous sodium sulfate
5. concentrationconcentrated under reduced pressure