5-Methoxycarbonyl-2-methylphenylboronic acid pinacol ester → HCID 90030246, compound

HRID 1488098Notes

Reaction equation

HRID 1488098 reaction equation
[C:1]([C:3]1[N:4]=[C:5]([CH2:19][OH:20])[NH:6][C:7]=1[C:8]1[C:9]([CH3:18])=[CH:10][C:11](C)=[C:12]([CH:16]=1)[C:13]([OH:15])=[O:14])#[N:2].CC1C=CC(C(OC)=O)=CC=1B1OC(C)(C)C(C)(C)O1.CC1C=C(C)C(B2OC(C)(C)C(C)(C)O2)=CC=1C(OC)=O>>[C:1]([C:3]1[N:4]=[C:5]([CH2:19][OH:20])[NH:6][C:7]=1[C:8]1[CH:16]=[C:12]([CH:11]=[CH:10][C:9]=1[CH3:18])[C:13]([OH:15])=[O:14])#[N:2]

Participants

4

Reactant 3

HCID 532171365-Methoxycarbonyl-2-methylphenylboronic acid pinacol ester2×HCID 59224686Methyl 2,4-dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoateHCID 90028965HCID 90028965, compound

Product 1

HCID 90030246HCID 90030246, compound

Procedure

The title compound was prepared using standard chemical manipulations and procedures similar to those used for the preparation of compound 219.6, except methyl 4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (compound 5.4) was used in place of methyl 2,4-dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (compound 160.1).

Sources & evidence

ORD record
ord-e9aca1e66b114664a66ce5e447db751e
Source dataset
uspto-grants-2016_08
Patent number
US09428502B2

Reaction notes

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