5-Methoxycarbonyl-2-methylphenylboronic acid pinacol ester → HCID 178425889, compound

HRID 1488107Notes

Reaction equation

HRID 1488107 reaction equation
[OH:1][CH2:2][C:3]1[NH:4][C:5]([C:9]2[C:10]([CH3:19])=[CH:11][C:12](C)=[C:13]([CH:17]=2)[C:14]([OH:16])=[O:15])=[C:6]([CH3:8])[N:7]=1.CC1C=CC(C(OC)=O)=CC=1B1OC(C)(C)C(C)(C)O1.CC1C=C(C)C(B2OC(C)(C)C(C)(C)O2)=CC=1C(OC)=O>>[OH:1][CH2:2][C:3]1[NH:4][C:5]([C:9]2[CH:17]=[C:13]([CH:12]=[CH:11][C:10]=2[CH3:19])[C:14]([OH:16])=[O:15])=[C:6]([CH3:8])[N:7]=1

Participants

4

Reactant 3

HCID 532171365-Methoxycarbonyl-2-methylphenylboronic acid pinacol ester2×HCID 59224686Methyl 2,4-dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoateHCID 178424688HCID 178424688, compound2×

Product 1

HCID 178425889HCID 178425889, compound

Procedure

The title compound was prepared using standard chemical manipulations and procedures similar to those used for the preparation of 5-(2-(hydroxymethyl)-4-methyl-1H-imidazol-5-yl)-2,4-dimethylbenzoic acid (compound 222.5), except methyl 4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (compound 5.4) was used in place of methyl 2,4-dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (compound 160.1).

Sources & evidence

ORD record
ord-83f45150718a4109aab160ee265ee9f0
Source dataset
uspto-grants-2016_08
Patent number
US09428502B2

Reaction notes

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