Sodium borohydride → HCID 178497365, compound

HRID 1488124Notes

Reaction equation

HRID 1488124 reaction equation
[CH:1]([C:3]1[N:4]=[C:5]([CH3:20])[NH:6][C:7]=1[C:8]1[C:9]([CH3:19])=[CH:10][C:11]([CH3:18])=[C:12]([CH:17]=1)[C:13]([O:15][CH3:16])=[O:14])=[O:2].[BH4-].[Na+]>CO>[OH:2][CH2:1][C:3]1[N:4]=[C:5]([CH3:20])[NH:6][C:7]=1[C:8]1[C:9]([CH3:19])=[CH:10][C:11]([CH3:18])=[C:12]([CH:17]=1)[C:13]([O:15][CH3:16])=[O:14]

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 178497364HCID 178497364, compound2×

Product 1

HCID 178497365HCID 178497365, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Into a 50-mL round-bottom flask, was placed a solution of methyl 5-(4-formyl-2-methyl-1H-imidazol-5-yl)-2,4-dimethylbenzoate (compound 236.2, 400 mg, 1.47 mmol) in methanol (20 mL). This was followed by the addition of NaBH4 (100 mg, 2.64 mmol) in several batches at 0° C. The reaction mixture was stirred for 1 h at room temperature, then was used for next step directly.

Workup

  1. customInto a 50-mL round-bottom flask, was placed

Sources & evidence

ORD record
ord-faa20b2519b0484d9354a3217336da99
Source dataset
uspto-grants-2016_08
Patent number
US09428502B2

Reaction notes

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