5-Methoxycarbonyl-2-methylphenylboronic acid pinacol ester → HCID 178497390, compound

HRID 1488135Notes

Reaction equation

HRID 1488135 reaction equation
[CH3:1][C:2]1[C:6]([CH3:7])=[C:5]([C:8]2[CH:9]=[C:10]([CH:15]=[CH:16][C:17]=2[CH3:18])[C:11]([O:13][CH3:14])=[O:12])[NH:4][N:3]=1.[CH3:19]C1C=C(C)C(B2OC(C)(C)C(C)(C)O2)=CC=1C(OC)=O.CC1C=CC(C(OC)=O)=CC=1B1OC(C)(C)C(C)(C)O1>>[CH3:1][C:2]1[C:6]([CH3:7])=[C:5]([C:8]2[C:17]([CH3:18])=[CH:16][C:15]([CH3:19])=[C:10]([CH:9]=2)[C:11]([O:13][CH3:14])=[O:12])[NH:4][N:3]=1

Participants

4

Reactant 3

HCID 532171365-Methoxycarbonyl-2-methylphenylboronic acid pinacol esterHCID 59224686Methyl 2,4-dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate2×HCID 178497724HCID 178497724, compound

Product 1

HCID 178497390HCID 178497390, compound

Procedure

The title compound was prepared using standard chemical manipulations and procedures similar to those used for the preparation of compound 59.2, except methyl 2,4-dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (compound 160.1) was used in place of methyl 4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (compound 5.4). m/z (ES+) 259 (M+H)+.

Sources & evidence

ORD record
ord-610e68d604c9456b93f8c8dd9c4e8f46
Source dataset
uspto-grants-2016_08
Patent number
US09428502B2

Reaction notes

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