反应详情

温度

80 °C

Into a 100-mL round-bottom flask, was placed a solution of ethyl 2-methyl-3-oxopropanoate (compound 249.1, 500 mg, 3.84 mmol) in ethanol (15 mL). Benzylhydrazine hydrochloride (730 mg, 4.66 mmol) was added and the reaction was stirred for 5 h at 80° C., then concentrated under reduced pressure. The residue was purified by a silica gel chromatography with dichloromethane/methanol (30:1) as eluent to obtain the title compound as a yellow oil (430 mg, 59%).

1. customInto a 100-mL round-bottom flask, was placed
2. concentrationconcentrated under reduced pressure
3. customThe residue was purified by a silica gel chromatography with dichloromethane/methanol (30:1) as eluent