3-(4-Methoxy-1H-pyrazol-5-yl)-4-methylbenzoic acid → 3-(4-Cyano-1H-pyrazol-5-yl)-4-methylbenzoic acid

HRID 1488159Notes

Reaction equation

HRID 1488159 reaction equation
COC1C=NNC=1C1C=C(C=CC=1C)C(O)=O.[C:18]([C:20]1[CH:21]=[N:22][NH:23][C:24]=1[C:25]1[CH:26]=[C:27]([CH:32]=[CH:33][C:34]=1[CH3:35])[C:28]([O:30]C)=[O:29])#[N:19].COC1C=NNC=1C1C=C(C=CC=1C)C(OC)=O>>[C:18]([C:20]1[CH:21]=[N:22][NH:23][C:24]=1[C:25]1[CH:26]=[C:27]([CH:32]=[CH:33][C:34]=1[CH3:35])[C:28]([OH:30])=[O:29])#[N:19]

Participants

4

Reactant 3

HCID 900296623-(4-Methoxy-1H-pyrazol-5-yl)-4-methylbenzoic acidHCID 90030040Methyl 3-(4-cyano-1H-pyrazol-5-yl)-4-methylbenzoate2×HCID 90030202Methyl 3-(4-methoxy-1H-pyrazol-5-yl)-4-methylbenzoate

Product 1

HCID 900292363-(4-Cyano-1H-pyrazol-5-yl)-4-methylbenzoic acid

Procedure

The title compound was prepared using standard chemical manipulations and procedures similar to those used for the preparation of compound 244.7, except methyl 3-(4-cyano-1H-pyrazol-5-yl)-4-methylbenzoate (compound 256.4) was used in place of methyl 3-(4-methoxy-1H-pyrazol-5-yl)-4-methylbenzoate (compound 244.6).

Sources & evidence

ORD record
ord-c53bed7404b442358eda9942ac43690f
Source dataset
uspto-grants-2016_08
Patent number
US09428502B2

Reaction notes

Loading…