3-(4-Cyano-1H-pyrazol-5-yl)-4-methylbenzoic acid → HCID 178425893, compound

HRID 1488162Notes

Reaction equation

HRID 1488162 reaction equation
[C:1]([C:3]1[CH:4]=[N:5][NH:6][C:7]=1[C:8]1[CH:9]=[C:10]([CH:14]=[CH:15][C:16]=1[CH3:17])[C:11]([OH:13])=[O:12])#[N:2].I[C:19]1NN=C(C)C=1C#N.IC1C(C#N)=CNN=1>>[C:1]([C:3]1[C:4]([CH3:19])=[N:5][NH:6][C:7]=1[C:8]1[CH:9]=[C:10]([CH:14]=[CH:15][C:16]=1[CH3:17])[C:11]([OH:13])=[O:12])#[N:2]

Participants

4

Reactant 3

HCID 900292363-(4-Cyano-1H-pyrazol-5-yl)-4-methylbenzoic acidHCID 178434629HCID 178434629, compound2×HCID 178510442HCID 178510442, compound2×

Product 1

HCID 178425893HCID 178425893, compound

Procedure

The title compound was prepared using standard chemical manipulations and procedures similar to those used for the preparation of compound 256.5, except 5-iodo-3-methyl-1H-pyrazole-4-carbonitrile (compound 257.4) was used in place 3-iodo-1H-pyrazole-4-carbonitrile (compound 256.1).

Sources & evidence

ORD record
ord-4f6539a277264608b42b67d427a49a6b
Source dataset
uspto-grants-2016_08
Patent number
US09428502B2

Reaction notes

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