Ammonia → HCID 90030787, compound

HRID 1488168Notes

Reaction equation

HRID 1488168 reaction equation
[I:1][C:2]1[NH:6][N:5]=[C:4]([C:7]([O:9]C)=O)[CH:3]=1.[NH3:11]>CO>[I:1][C:2]1[NH:6][N:5]=[C:4]([C:7]([NH2:11])=[O:9])[CH:3]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 90029718HCID 90029718, compound2×

Product 1

HCID 90030787HCID 90030787, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
60 °C

Procedure

Into a 100-mL round-bottom flask, was placed a solution of methyl 5-iodo-1H-pyrazole-3-carboxylate (compound 260.3, 900 mg, 3.57 mmol) in methanol (5 mL). Ammonia (25% aq.) (15 mL) was added and the resulting solution was stirred overnight at 60° C., then cooled and concentrated under reduced pressure to obtain the title compound as a white solid (0.8 g, 95%).

Workup

  1. customInto a 100-mL round-bottom flask, was placed
  2. temperaturecooled
  3. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-e1d0879729584052aeb3daa4fe06e796
Source dataset
uspto-grants-2016_08
Patent number
US09428502B2

Reaction notes

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