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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 14882Generated: October 25, 2026

Acetaldehyde → 2-(2-{[3-(2-Chloro-pyrimidin-4-yl)-benzyl]-ethyl-amino}-ethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

https://huagongshe.com/reaction/14882

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAcetaldehydeHCID 177—
Reactant2-{2-[3-(2-Chloro-pyrimidin-4-yl)-benzylamino]-ethyl}-pyrrolidine-1-carboxylic acid tert-butyl esterHCID 86603301—
Product2-(2-{[3-(2-Chloro-pyrimidin-4-yl)-benzyl]-ethyl-amino}-ethyl)-pyrrolidine-1-carboxylic acid tert-butyl esterHCID 86603300—

Reaction Steps

Intermediate 106 was coupled with acetaldehyde following procedure E. LC-MS showed the product had the expected M+H+ of 445.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07732444B2
Source datasetuspto-grants-2010_06
ORD IDord-9e4351bbb0594b528ee6132d79e46065
Source noteuspto-grants-2010_06