Methyl acetoacetate → Methyl 2-[(dimethylamino)methylene]acetoacetate

Participants

Reaction Conditions

Reaction Steps

Into a 250-mL round-bottom flask, was placed methyl 3-oxobutanoate (10.8 g, 92.6 mmol) and (dimethoxymethyl)dimethylamine (12.7 mL, 95.3 mmol). The resulting solution was stirred for 2.5 h at 80° C., then concentrated under reduced pressure to yield 14.5 g (crude) of the title compound as a red solid.

Provenance & Evidence