5-Methoxycarbonyl-2-methylphenylboronic acid pinacol ester → HCID 178497722, compound

HRID 1488218Notes

Reaction equation

HRID 1488218 reaction equation
C([O:8][CH2:9][C:10]1[NH:11][C:12]([C:19]2[C:20]([CH3:30])=[CH:21][C:22](C)=[C:23]([CH:28]=2)[C:24]([O:26][CH3:27])=[O:25])=[C:13]([C:15]([F:18])([F:17])[F:16])[N:14]=1)C1C=CC=CC=1.CC1C=CC(C(OC)=O)=CC=1B1OC(C)(C)C(C)(C)O1.CC1C=C(C)C(B2OC(C)(C)C(C)(C)O2)=CC=1C(OC)=O>>[OH:8][CH2:9][C:10]1[NH:11][C:12]([C:19]2[CH:28]=[C:23]([CH:22]=[CH:21][C:20]=2[CH3:30])[C:24]([O:26][CH3:27])=[O:25])=[C:13]([C:15]([F:16])([F:18])[F:17])[N:14]=1

Participants

4

Reactant 3

HCID 532171365-Methoxycarbonyl-2-methylphenylboronic acid pinacol ester2×HCID 59224686Methyl 2,4-dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoateHCID 178497370HCID 178497370, compound

Product 1

HCID 178497722HCID 178497722, compound

Procedure

The title compound was prepared using standard chemical manipulations and procedures similar to those used for the preparation of compound 219.4, except methyl 4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (compound 5.4) was used instead of methyl 2,4-dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (compound 160.1).

Sources & evidence

ORD record
ord-6eefd950eeab4b909c0be7a9f133d3fa
Source dataset
uspto-grants-2016_08
Patent number
US09428502B2

Reaction notes

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