HCID 178497722, compound → HCID 178425890, compound

Participants

Reaction Conditions

Reaction Steps

Into a 100-mL round-bottom flask, was placed methyl 3-(2-(hydroxymethyl)-4-(trifluoromethyl)-1H-imidazol-5-yl)-4-methylbenzoate (compound 284.1, 2 g, 6.36 mmol), HBr (40% in AcOH) (50 mL). The reaction mixture was stirred for 12 h at 80° C. The crude product (100 mL) was purified by Flash-Prep-HPLC with the following conditions (IntelFlash-1): mobile phase, CH3CN:H2O=1:1; Detector, UV 254 nm to yield 1 g (52%) of the title compound as a light yellow solid.

Provenance & Evidence