4-Methoxycyclohexane-1-carbaldehyde → HCID 178497712, compound

HRID 1488228Notes

Reaction equation

HRID 1488228 reaction equation
[CH:1]1([C:4]2[NH:5][C:6]([C:10]3[C:11]([CH3:21])=[CH:12][C:13](C)=[C:14]([CH:19]=3)[C:15]([O:17][CH3:18])=[O:16])=[C:7]([CH3:9])[N:8]=2)[CH2:3][CH2:2]1.[CH3:22][O:23][CH:24]1CCC(C=O)[CH2:26][CH2:25]1.CC1C=CC(C(OC)=O)=CC=1B1OC(C)(C)C(C)(C)O1.CC1C=C(C)C(B2OC(C)(C)C(C)(C)O2)=CC=1C(OC)=O>>[CH3:22][O:23][CH:24]1[CH2:25][CH2:26][CH:1]([C:4]2[NH:5][C:6]([C:10]3[CH:19]=[C:14]([CH:13]=[CH:12][C:11]=3[CH3:21])[C:15]([O:17][CH3:18])=[O:16])=[C:7]([CH3:9])[N:8]=2)[CH2:2][CH2:3]1

Participants

5

Reactant 4

HCID 2979194-Methoxycyclohexane-1-carbaldehyde2×HCID 532171365-Methoxycarbonyl-2-methylphenylboronic acid pinacol ester2×HCID 59224686Methyl 2,4-dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate2×HCID 178497336HCID 178497336, compound

Product 1

HCID 178497712HCID 178497712, compound

Procedure

The title compound was prepared using standard chemical manipulations and procedures similar to those used for the preparation of compound 160.3, except 4-methoxycyclohexanecarbaldehyde (compound 300.2) was used instead of cyclopropanecarbaldehyde and methyl 4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (compound 5.4) was used instead of except methyl 2,4-dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (compound 160.1).

Sources & evidence

ORD record
ord-cbdbc87fdc964fa793c5d75821933081
Source dataset
uspto-grants-2016_08
Patent number
US09428502B2

Reaction notes

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