HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → HCID 178485555, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | HCID 178433052 | HCID 178433052 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178485555 | HCID 178485555 | 67.1% |
Reaction Steps
2-Methyl-1H-imidazole-4-carboxylic acid (378 mg, 3 mmol), EDCI (745 mg, 3.9 mmol), HOBt (253 mg, 1.5 mmol), DIEA (1.6 mL, 9 mmol) and methyl amine (2M in THF) (3.6 mL, 7.2 mmol) were dissolved in DMF (10 mL) and stirred at room temperature for 16 hours. After removal of DMF, the residue was dry loaded and purified by flash chromatography (SiO2, 0-10% methanol in DCM and 1% NH4OH) to give 280 mg (67%) of the title compound. m/z (ES+) 140 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09428502B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-f8554a003adc435d8021997c9e22fb4a |
| Source note | uspto-grants-2016_08 |