4,4,4-Trifluorobutan-2-one → 4,4,4-Trifluoro-2-oxobutanal
Reaction equation
CC(O)=[O:3].O.[F:6][C:7]([F:13])([F:12])[CH2:8][C:9](=[O:11])[CH3:10]>O1CCOCC1>[F:6][C:7]([F:13])([F:12])[CH2:8][C:9](=[O:11])[CH:10]=[O:3]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 100 °C
Procedure
To a solution of SeO2 (4.23 g, 38.1 mmol) in dioxane (25 mL) was added AcOH/H2O (1 mL/1 mL). 4,4,4-Trifluorobutan-2-one (3.81 mL, 31.7 mmol) was added dropwise to the above reaction mixture. The resulting solution was stirred overnight at 100° C. The solution was used in the next step without any further work-up or purification.
Workup
- customThe solution was used in the next step without any further work-up or purification
Sources & evidence
- ORD record
- ord-ffba34d1e2674065bd8c7ade01904ce5
- Source dataset
- uspto-grants-2016_08
- Patent number
- US09428502B2
Reaction notes
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