HCID 178427818, compound → HCID 178432706, compound

HRID 1488235Notes

Reaction equation

HRID 1488235 reaction equation
[CH3:1][C:2]1[NH:3][C:4]([C:8]2[CH:9]=[C:10]([CH:25]=[CH:26][C:27]=2F)[C:11]([N:13]2[CH2:16][CH:15]([C:17]3[CH:24]=[CH:23][C:20]([C:21]#[N:22])=[CH:19][CH:18]=3)[CH2:14]2)=[O:12])=[C:5]([CH3:7])[N:6]=1.CC1C(C)=C(C2C(F)=CC(C)=C(C=2)C([N:43]2[CH2:46][CH:45](C3C=CC(C#N)=CC=3)[CH2:44]2)=O)NN=1>>[N:43]1([C:27]2[CH:26]=[CH:25][C:10]([C:11]([N:13]3[CH2:16][CH:15]([C:17]4[CH:18]=[CH:19][C:20]([C:21]#[N:22])=[CH:23][CH:24]=4)[CH2:14]3)=[O:12])=[CH:9][C:8]=2[C:4]2[NH:3][C:2]([CH3:1])=[N:6][C:5]=2[CH3:7])[CH2:46][CH2:45][CH2:44]1

Participants

3

Reactant 2

HCID 178427818HCID 178427818, compoundHCID 178432705HCID 178432705, compound2×

Product 1

HCID 178432706HCID 178432706, compound

Procedure

The title compound was prepared using standard chemical manipulations and procedures similar to those used for the preparation of compound 377, except 4-(1-(3-(2,4-dimethyl-1H-imidazol-5-yl)-4-fluorobenzoyl)azetidin-3-yl)benzonitrile (compound 376.2) was used instead of 4-(1-(5-(3,4-dimethyl-1H-pyrazol-5-yl)-4-fluoro-2-methylbenzoyl)azetidin-3-yl)benzonitrile (compound 377.2). m/z (ES+) 412 (M+H)+.

Sources & evidence

ORD record
ord-f6eff3ee56d34beeb75554ac318f318d
Source dataset
uspto-grants-2016_08
Patent number
US09428502B2

Reaction notes

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