反应详情

To a stirred solution of benzyl 6-{bis[2-({2-[(α-L-fucopyranosyl)oxy]ethyl}amino)-2-oxoethyl]amino}-6-oxohexanoate (900 mg, 1.233 mmol) in H2O (5 mL) at rt was added dihydroxypalladium (866 mg, 1.233 mmol). The mixture was degassed and then stirred under a balloon of H2. After stirring at rt under H2 for 16 hr, the reaction mixture was filtered through a Celite pad and washed with CH3OH (3×10 mL). The filtrate was concentrated to give the title compound. LC-MS Method A: m/e=640.17 [M+1]; Rt=0.98 min.

1. customThe mixture was degassed
2. stirringAfter stirring at rt under H2 for 16 hr
3. filtrationthe reaction mixture was filtered through a Celite pad
4. washwashed with CH3OH (3×10 mL)
5. concentrationThe filtrate was concentrated