HCID 19063418, compound → HCID 19063427, compound

HRID 1488348Notes

Reaction equation

HRID 1488348 reaction equation
[C:1](=[O:35])([O:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34])[O:2][CH:3]([O:5][C:6](=[O:23])[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([O:15]CC1C=CC=CC=1)=[O:14])[CH3:4]>C(O)(=O)C.[Pd]>[C:1](=[O:35])([O:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34])[O:2][CH:3]([O:5][C:6](=[O:23])[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([OH:15])=[O:14])[CH3:4]

Participants

4

Reactant 1

HCID 19063418HCID 19063418, compound

Product 1

HCID 19063427HCID 19063427, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolvent

Procedure

To a solution of 1-(7-benzyloxycarbonylheptanoyloxy)ethyl decyl carbonate (Example 1ac(iv), 4.0 g, 7.9 mmol) in acetic acid (15 ml) was added a catalytic amount of palladium on charcoal (150 mg). The mixture was hydrogenated with H2 at ambient temperature for 5 hours. Acetic acid was removed under reduced pressure. The residue was purified by column chromatography using n-heptane/ethyl acetate (4:1) as eluent.

Workup

  1. customAcetic acid was removed under reduced pressure
  2. customThe residue was purified by column chromatography

Sources & evidence

ORD record
ord-08c05f7b6b184e848ba18d9e691a584a
Source dataset
uspto-grants-1997_10
Patent number
US05674468

Reaction notes

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