2,5-Dichlorotoluene → Methyl 5-(2,5-Dichlorophenyl)pentanoate

HRID 1488373Notes

Reaction equation

HRID 1488373 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[CH3:9].[CH3:10][O:11][C:12](OC)([O:17]C)[CH2:13][CH2:14][CH2:15]Br>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[CH2:9][CH2:15][CH2:14][CH2:13][C:12]([O:11][CH3:10])=[O:17]

Participants

3

Reactant 2

HCID 295722,5-DichlorotolueneHCID 5187924Trimethyl 4-bromoorthobutyrate

Product 1

HCID 22013526Methyl 5-(2,5-Dichlorophenyl)pentanoate

Procedure

The anion of 2,5-dichlorotoluene was reacted with trimethyl 4-bromoorthobutyrate to produce methyl 5-(2,5-dichlorophenyl)pentanoate after mild hydrolytic work-up. Competitor A was prepared by LiOH hydrolysis of the methyl ester.

Sources & evidence

ORD record
ord-b5a74dec1d604f5cb76d5a20f3d421a9
Source dataset
uspto-grants-1997_10
Patent number
US05674697

Reaction notes

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