HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 2-[2-(3-fluoro-4-nitrophenoxymethyl)-5-methylphenoxy]propionate → Methyl 2-[2-(4-amino-3-fluorophenoxymethyl)-5-methylphenoxy]propionate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 2-[2-(3-fluoro-4-nitrophenoxymethyl)-5-methylphenoxy]propionate | HCID 18981042 | — |
| Catalyst | Iron | HCID 23925 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | Methyl 2-[2-(4-amino-3-fluorophenoxymethyl)-5-methylphenoxy]propionate | HCID 18981068 | 61.3% |
Reaction Steps
By the method of Example 2, Step A, 3.35 g (0.0091 mole) of methyl 2-[2-(3-fluoro-4-nitrophenoxymethyl)-5-methylphenoxy]propionate was reacted with 2.80 g (0.050 mole) of powdered iron in 100 mL of acetic acid, yielding 1.86 g of methyl 2-[2-(4-amino-3-fluorophenoxymethyl)-5-methylphenoxy]propionate as an amber syrup. The NMR and IR spectra were consistent with the proposed structure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05674810 |
| Source dataset | uspto-grants-1997_10 |
| ORD ID | ord-abac20ca07b142a58df99d5683b9dcd9 |
| Source note | uspto-grants-1997_10 |