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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 14885Generated: October 30, 2026

2-(1H-Indol-3-ylmethyl)-piperazine-1-carboxylic acid tert-butyl ester → 4-[3-(2-Chloro-pyrimidin-4-yl)-benzyl]-2-(1H-indol-3-ylmethyl)-piperazine-1-carboxylic acid tert-butyl ester

https://huagongshe.com/reaction/14885

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(1H-Indol-3-ylmethyl)-piperazine-1-carboxylic acid tert-butyl esterHCID 22342889—
Reactant3-(2-Chloro-pyrimidin-4-yl)-benzaldehydeHCID 24901965—
Product4-[3-(2-Chloro-pyrimidin-4-yl)-benzyl]-2-(1H-indol-3-ylmethyl)-piperazine-1-carboxylic acid tert-butyl esterHCID 86603303—

Reaction Steps

Intermediate 1 was coupled with 2-(1H-Indol-3-ylmethyl)-piperazine-1-carboxylic acid tert-butyl ester following procedure B. LC-MS showed the product had the expected M+H+ of 518.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07732444B2
Source datasetuspto-grants-2010_06
ORD IDord-01ecf99962f047358aff6e545966bda5
Source noteuspto-grants-2010_06