Benzyl Alcohol → HCID 67725415, compound

Participants

Reaction Steps

To a solution of 203 mg (0.318 mmol) of biphenyl bicyclic imidazole (trityl protected Example 11) and 200 μL (1.9 mmol) of benzyl alcohol in 0.5 mL of anhydrous chloroform was added 57 mg (0.32 mmol) of NBS in one portion. The resulting orange-red solution was stirred at room temperature for 2 hours, and the reaction mixture was washed with aqueous sodium bisulfite, water,and brine. The combined extracts were dried (MgSO4) and concentrated in vacuo. The residue was used directly in the subsequent Step 2 without further purification.

Provenance & Evidence