HCID 178418361, compound → HCID 178440672, compound

HRID 1488659Notes

Reaction equation

HRID 1488659 reaction equation
[CH2:1]([C:5]1[N:13]2[C:8]([C:9](=[N:31]O)[CH2:10][CH2:11][CH:12]2[C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[C:26]3[NH:30][N:29]=[N:28][N:27]=3)=[CH:16][CH:15]=2)=[CH:7][CH:6]=1)[CH2:2][CH2:3][CH3:4].[H][H]>[Pd].CO>[CH2:1]([C:5]1[N:13]2[C:8]([CH:9]([NH2:31])[CH2:10][CH2:11][CH:12]2[C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[C:26]3[NH:27][N:28]=[N:29][N:30]=3)=[CH:16][CH:15]=2)=[CH:7][CH:6]=1)[CH2:2][CH2:3][CH3:4]

Participants

5

Reactant 2

HCID 178418361HCID 178418361, compoundHCID 178440673HCID 178440673, compound

Product 1

HCID 178440672HCID 178440672, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Alternatively, the title compound of Example 1955 can be prepared from the corresponding oxime. A suspension of the biphenyl imidazolyl oxime (0.059 mmol, the title compound of Example 1953) and 20 mg (0.0188 mmol) of 10% palladium on charcoal in 1.5 mL of methanol is stirred at room temperature under 50 psi of hydrogen gas until the reaction is complete. The mixture is filtered through a pad of celite, concentrated in vacuo and purified to give the title compound of Example 1955.

Workup

  1. filtrationThe mixture is filtered through a pad of celite
  2. concentrationconcentrated in vacuo
  3. custompurified

Sources & evidence

ORD record
ord-0aab45d6a6034236894ffd4bf9f5f638
Source dataset
uspto-grants-1997_10
Patent number
US05674879

Reaction notes

Loading…