HCID 178418361, compound → HCID 178441906, compound

HRID 1488660Notes

Reaction equation

HRID 1488660 reaction equation
[CH2:1]([C:5]1[N:9]2[CH:10]([C:14]3[CH:19]=[CH:18][C:17]([C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=4[C:26]4[NH:30][N:29]=[N:28][N:27]=4)=[CH:16][CH:15]=3)[CH2:11][CH:12]=[CH:13][C:8]2=[N:7][N:6]=1)[CH2:2][CH2:3][CH3:4].[H][H]>[Pd].C(O)C>[CH2:1]([C:5]1[N:9]2[CH:10]([C:14]3[CH:19]=[CH:18][C:17]([C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=4[C:26]4[NH:30][N:29]=[N:28][N:27]=4)=[CH:16][CH:15]=3)[CH2:11][CH2:12][CH2:13][C:8]2=[N:7][N:6]=1)[CH2:2][CH2:3][CH3:4]

Participants

5

Reactant 2

HCID 178418361HCID 178418361, compoundHCID 178441905HCID 178441905, compound

Product 1

HCID 178441906HCID 178441906, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A suspension of bicyclic olefin triazole 0.1 mmol, the title compound of Example 3257) and 20 mg (0.019 mmol) of 10% palladium on charcoal in 2 mL of absolute ethanol is agitated on a Parr apparatus under 50 psi of hydrogen gas at room temperature until the reaction is complete. The mixture is filtered through a pad of celite, concentrated in vacuo and purified to give the title compound of Example 3259.

Workup

  1. filtrationThe mixture is filtered through a pad of celite
  2. concentrationconcentrated in vacuo
  3. custompurified

Sources & evidence

ORD record
ord-f28f8d72c57a4d67957c122790ffa766
Source dataset
uspto-grants-1997_10
Patent number
US05674879

Reaction notes

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