(S)-5-Methoxy-N-propyl-1,2,3,4-tetrahydronaphthalen-2-amine → HCID 54162987, compound

HRID 1488711Notes

Reaction equation

HRID 1488711 reaction equation
[CH2:1]([N:4]([C@H:14]1[CH2:23][CH2:22][C:21]2[C:16](=[CH:17][CH:18]=[CH:19][C:20]=2[O:24][CH3:25])[CH2:15]1)[C:5](=[O:13])[CH2:6][CH2:7][CH2:8][CH2:9][C:10]([OH:12])=[O:11])[CH2:2][CH3:3].C(N[C@H]1CCC2C(=CC=C[C:36]=2[O:40]C)C1)CC>>[CH2:1]([N:4]([C@H:14]1[CH2:23][CH2:22][C:21]2[C:16](=[CH:17][CH:18]=[C:19]([O:40][CH3:36])[C:20]=2[O:24][CH3:25])[CH2:15]1)[C:5](=[O:13])[CH2:6][CH2:7][CH2:8][CH2:9][C:10]([OH:12])=[O:11])[CH2:2][CH3:3]

Participants

3

Reactant 2

HCID 10727609(S)-5-Methoxy-N-propyl-1,2,3,4-tetrahydronaphthalen-2-amineHCID 70192713HCID 70192713, compound2×

Product 1

HCID 54162987HCID 54162987, compound

Procedure

(S)-N-propyl-N-[5-methoxy-1,2,3,4-tetrahydro-2-naphthyl]-5-carboxypentanamide (Intermediate 31) starting from (S)-N-propyl-5-methoxy-1,2,3,4-tetrahydro-2-naphthylamine, prepared as described in J. Med. Chem., 29, 912 (1986).

Workup

  1. customprepared

Sources & evidence

ORD record
ord-d899b4c9083d4ba2a640ab822a3c5bcf
Source dataset
uspto-grants-1997_10
Patent number
US05674909

Reaction notes

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