HCID 22853151, compound → HCID 22878046, compound

HRID 1488712Notes

Reaction equation

HRID 1488712 reaction equation
[ClH:1].[CH2:2]([NH:5][C@H:6]1[CH2:15][CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[C:11]([O:24][CH2:25][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[C:12]=2[O:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH2:7]1)[CH2:3][CH3:4].[N+:32]([C:35]1[CH:40]=[CH:39][C:38]([CH2:41][C:42]([NH:44][CH2:45][CH2:46][CH2:47][CH2:48][CH2:49][C:50](O)=O)=O)=[CH:37][CH:36]=1)([O-:34])=[O:33].Br.C(N[C@H]1CCC2C(=CC=C(OC)C=2OC)C1)CC.COC1C=CC(SCC(NCCCCCC(O)=O)=O)=CC=1>>[ClH:1].[ClH:1].[CH2:2]([N:5]([C@H:6]1[CH2:15][CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[C:11]([O:24][CH2:25][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[C:12]=2[O:16][CH2:17][C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH2:7]1)[CH2:50][CH2:49][CH2:48][CH2:47][CH2:46][CH2:45][NH:44][CH2:42][CH2:41][C:38]1[CH:39]=[CH:40][C:35]([N+:32]([O-:34])=[O:33])=[CH:36][CH:37]=1)[CH2:3][CH3:4]

Participants

5

Reactant 4

HCID 22853151HCID 22853151, compoundHCID 22877979HCID 22877979, compoundHCID 22906015HCID 22906015, compoundHCID 22906083HCID 22906083, compound

Product 1

HCID 22878046HCID 22878046, compound

Procedure

By working in a way similar to that described in example 18 but by using Intermediate 27, prepared as described in example 14, and Intermediate 10, prepared as described in example 1, instead of (S)-N-propyl-5,6-dimethoxy-1,2,3,4-tetrahydro-2-naphthylamine hydrobromide and of Intermediate 1 respectively, Intermediate 37 was obtained.

Workup

  1. customprepared
  2. customprepared

Sources & evidence

ORD record
ord-68638384b2b4488daa0a880001d3f2cf
Source dataset
uspto-grants-1997_10
Patent number
US05674909

Reaction notes

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