Sodium ion → Tert-butyl 4-((5-chloro-2-(5-cyanopyrazin-2-ylamino)pyridin-4-ylamino)methyl)piperidine-1-carboxylate
Reaction equation
[Br:24][c:25]1[n:26][cH:27][c:28]([C:31]#[N:32])[n:29][cH:30]1.[CH3:79][C:80]([CH3:81])([O-:82])[CH3:83].[CH:109](=[CH:110][C:111]([CH:112]=[CH:113][c:114]1[cH:115][cH:116][cH:117][cH:118][cH:119]1)=[O:120])[c:121]1[cH:122][cH:123][cH:124][cH:125][cH:126]1.[CH:127](=[CH:128][C:129]([CH:130]=[CH:131][c:132]1[cH:133][cH:134][cH:135][cH:136][cH:137]1)=[O:138])[c:139]1[cH:140][cH:141][cH:142][cH:143][cH:144]1.[CH:85]([Cl:86])([Cl:87])[Cl:88].[CH:91](=[CH:92][C:93]([CH:94]=[CH:95][c:96]1[cH:97][cH:98][cH:99][cH:100][cH:101]1)=[O:102])[c:103]1[cH:104][cH:105][cH:106][cH:107][cH:108]1.[NH2:1][c:2]1[n:3][cH:4][c:5]([Cl:23])[c:6]([NH:8][CH2:9][CH:10]2[CH2:11][CH2:12][N:13]([C:16](=[O:17])[O:18][C:19]([CH3:20])([CH3:21])[CH3:22])[CH2:14][CH2:15]2)[cH:7]1.[Na+:84].[O:145]1[CH2:146][CH2:147][O:148][CH2:149][CH2:150]1.[Pd:89].[Pd:90].[c:33]1([P:34]([c:35]2[cH:36][cH:37][cH:38][cH:39][cH:40]2)[c:41]2[cH:42][cH:43][c:44]3[c:45]([cH:46][cH:47][cH:48][cH:49]3)[c:50]2-[c:51]2[c:52]3[c:53]([cH:54][cH:55][cH:56][cH:57]3)[cH:58][cH:59][c:60]2[P:61]([c:62]2[cH:63][cH:64][cH:65][cH:66][cH:67]2)[c:68]2[cH:69][cH:70][cH:71][cH:72][cH:73]2)[cH:74][cH:75][cH:76][cH:77][cH:78]1>>[NH:1]([c:2]1[n:3][cH:4][c:5]([Cl:23])[c:6]([NH:8][CH2:9][CH:10]2[CH2:11][CH2:12][N:13]([C:16](=[O:17])[O:18][C:19]([CH3:20])([CH3:21])[CH3:22])[CH2:14][CH2:15]2)[cH:7]1)[c:25]1[n:26][cH:27][c:28]([C:31]#[N:32])[n:29][cH:30]1Participants
10
Reactant 9
Product 1
Sources & evidence
- ORD record
- ord-eca9d61558484d56b2f99db7c3f363c3
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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