反应详情

The mixture of 2-mercaptobenzimidazole (29.30 g, 0.195 mole) and butyl isocyanate (48.3 mL, 0.33 mole) in a 500 ml of round-bottom flask equipped with a condenser was heated to 130°-140° C. in an oil bath for 45 min. After the reaction mixture was cooled to room temperature, the solid was filtered, washed with hexane, and dried under vacuum to give 43.48 g (89%) of 1-(butylcarbamoyl)-1,3-dihydrobenzimidazole-2-thione as white crystals: mp 179°-180° C.

1. customequipped with a condenser
2. temperaturewas heated to 130°-140° C. in an oil bath for 45 min
3. filtrationthe solid was filtered
4. washwashed with hexane
5. customdried under vacuum