Hydrochloric Acid → HCID 131720227, compound

Participants

Reaction Steps

The procedure is carried out as in Example 1 but starting with 0.84 g of 1-(5-chloro-1-oxo-2-indanyl)imidazole-2-carboxamide, a total of 55 ml of methanol and 4 ml of a 12N aqueous hydrochloric acid solution. 0.64 g of 8-chloro-5H, 10H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one hydrochloride is thus obtained which decomposes without melting above 300° C. [NMR spectrum: (200 MHz; DMSO-d6 ; δ in ppm): 4.07 [s, 2H: --CH2-- in position 10 (observed in DMSO-d6 plus a few drops of CD3COOD-d4)]; 7.55 (dd, J=8 and 2 Hz 1H: --H7); 7.76 (d, J=2 Hz, 1H: --H9); 7.95 (d, J=8 Hz, 1H: --H6); 7.95 and 8.25 (2d, J=1.5 Hz, 1H each: --H of imidazole); 13.00 (unresolved complex, 1H: --CONH--)].

Provenance & Evidence