2-Bromo-2,3-dihydro-4-fluoro-1H-inden-1-one → 2-Bromo-5,6-dichloro-2,3-dihydro-1H-inden-1-one

Participants

Reaction Steps

The 2-bromo-5,6-dichloro-1-indanone is prepared as in Example 14 for the preparation of 2-bromo-4-fluoro-1-indanone but starting with 5.48 g of 5,6-dichloro-1-indanone, 16.1 g of copper bromide and 175 ml of dioxane. After purifying by silica column chromatography with an ethyl acetate-cyclohexane mixture (10-90 by volume) as eluent, 4.07 g of 2-bromo-5,6-dichloro-1-indanone are obtained which melt at 85° C.

Provenance & Evidence