HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 4,5-dichloro-2,3-dihydro-1H-inden-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Reactant | 3-(2,3-Dichlorophenyl)propanoic acid | HCID 12595101 | — |
| Reactant | 6,7-Dichloro-2,3-dihydro-1H-inden-1-one | HCID 21986081 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4,5-dichloro-2,3-dihydro-1H-inden-1-one | HCID 22903622 | — |
Reaction Steps
The 4,5-dichloro-1-indanone is prepared as in Example 15 for the preparation of 6,7-dichloro-1-indanone but star6ing with 26 g of 3-(2,3-dichlorophenyl)propionic acid, 138 ml of thionyl chloride, 550 ml of anhydrous dichloromethane and 20.5 g of aluminium chloride. After recrystallization from 100 ml of boiling ethanol, 12.67 g of 4,5-dichloro-1-indanone are thus obtained which melt at 78° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05677306 |
| Source dataset | uspto-grants-1997_10 |
| ORD ID | ord-217cfdc3855e4f09968b1529914f0f7b |
| Source note | uspto-grants-1997_10 |