Sulfuric Acid → HCID 70084284, compound

Participants

Reaction Conditions

Reaction Steps

1 g of 9-bromo-5H, 10H-imidazo[1,2-a]indeno-[1,2-e]pyrazin-4-one is added to 6 ml of concentrated sulphuric acid (20N) at a temperature close to 0° C. 0.3 g of potassium nitrate is then added in two portions to this solution while maintaining the temperature between 0° and 5° C. The reaction medium is stirred for 18 hours at 20° C., then poured into 50 ml of ice-cold water. The insoluble matter is filtered, washed with 50 ml of ethyl acetate and dried under reduced pressure (15 mmHg; 2 kPa) at 50° C. 0.77 g of 8-nitro-9-bromo-5H, 10H-imidazo[1,2-a]indeno[1,2-e]-pyrazin-4-one is thus obtained which melts above 260° C. (analysis: % calculated C: 44.98, H: 2.03, Br: 23.02, N: 16.14, % found C: 45.40, H: 2.20, Br: 21.30, N: 15.70).

Provenance & Evidence