Dimethylamine → HCID 136395933, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-[4-(chloromethyl)-phenyl]-5,6-dihydro-1,2,4-triazolo[4,3-c]-quinazolin-3-one (Compound 20) (150 mg, 0.48 mmol) and dimethylamine (1 ml, 40% in H2O) in THF was heated at 40° C. for 1.5 hours. The reaction was extracted with CH2Cl2 (3×50 ml) and the combined organic layers were dried over Na2SO4 and evaporated under reduced pressure. The residue was dissolved in ethyl acetate and saturated HCl/ethyl acetate solution was added to yield 2-[4-(N,N-dimethylaminomethyl)phenyl]-5,6-dihydro-1,2,4-triazolo-[4,3-c]quinazolin-3-one hydrochloride (Compound 21), m.p. 244°-247° C.

Provenance & Evidence