4-Bromobutanol → HCID 131720230, compound

HRID 1489059Notes

Reaction equation

[C:1]([OH:6])(=[O:5])[C:2]([OH:4])=[O:3].O[CH2:8][CH2:9][CH2:10][CH2:11][S:12][C:13]1[C:17]([CH:18]2[CH:23]3[CH2:24][CH2:25][N:20]([CH2:21][CH2:22]3)[CH2:19]2)=[N:16][S:15][N:14]=1.BrCCCC[OH:31]>>[C:1]([OH:6])(=[O:5])[C:2]([OH:4])=[O:3].[CH2:11]([S:12][C:13]1[C:17]([CH:18]2[CH:23]3[CH2:24][CH2:25][N:20]([CH2:21][CH2:22]3)[CH2:19]2)=[N:16][S:15][N:14]=1)[C:10](=[O:31])[CH2:9][CH3:8]

Participants

Reactant 2

HCID 1183884-Bromobutanol

HCID 21708578HCID 21708578, compound2×

Product 1

HCID 131720230HCID 131720230, compound

Procedure

3-(3-(4-Hydroxybutylthio)-1,2,5-thiadiazol-4-yl)-1-azabicyclo[2.2.2]octane oxalate (Compound 219) M.p. 160°-161° C., from 1-bromo-4-hydroxybutane.

Sources & evidence

ORD record: ord-dc36aa8ffe5b4b93befe5c1e00b6297b
Source dataset: uspto-grants-1997_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05677313

Reaction notes

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