HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 6-(2-Methylbenzoylamino)nicotinic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 2-Methylbenzoyl chloride | HCID 70276 | — |
| Reactant | Methyl 6-aminonicotinate | HCID 737487 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 6-(2-Methylbenzoylamino)nicotinic acid methyl ester | HCID 54003775 | 80.2% |
Reaction Steps
To a solution of 6-aminonicotinic acid methyl ester (4 g) in pyridine (40 ml) is added with stirring 2-methylbenzoyl chloride (6.73 g) under ice-cooling, and the mixture is stirred at room temperature overnight. To the reaction solution is added water, and the precipitated crystals are collected by filtration, and dried to give 6-(2-methylbenzoylamino)nicotinic acid methyl ester (5.7 g) as white powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05677299 |
| Source dataset | uspto-grants-1997_10 |
| ORD ID | ord-492f7d8a74404b6b8e0d41d2302b07e8 |
| Source note | uspto-grants-1997_10 |