HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroform → 7-Bromo-1H-indol-5-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroform | HCID 6212 | — |
| Reactant | Hydrazine | HCID 9321 | — |
| Reactant | 7-bromo-5-nitro-1H-indole | HCID 3860326 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 7-Bromo-1H-indol-5-amine | HCID 15434500 | 71.4% |
Reaction Steps
A solution of 7-bromo-5-nitroindole (0.68 g, 2.8 mmol), hydrazine (1.0 mL, 31 mmol) and 10% Pd/C (50 mg) in 50 mL of isopropanol was stirred at reflux for 2 h. The reaction mixture was filtered and concentrated in vacuo, yielding oily residue which was subjected to column chromatography (CHCl3, neat) to produce 0.41 g (2.0 mmol, 70%) of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05677321 |
| Source dataset | uspto-grants-1997_10 |
| ORD ID | ord-9da9a24da8ee414889dae601dc0632f1 |
| Source note | uspto-grants-1997_10 |