2-Benzylidenehydrazono-3-ethoxycarbonylmethyl-1-methoxycarbonylmethylimidazolidin-4-one → 7-Ethoxycarbonylmethyl-1,4,5,7-tetraazabicyclo[4,3,0]-nonan-5-ene-3,8-dione

Participants

Reaction Steps

To 230 mg of the 2-benzylidenehydrazono-3-ethoxycarbonylmethyl-1-methoxycarbonylmethylimidazolidin-4-one obtained in the above Referential Example 2 was added 10 ml of 0.5N hydrochloric acid and the mixture was steam-distilled for 40 minutes. After cooling, the reaction mixture was concentrated under reduced pressure and the residue was charged on silica gel column chromatography, followed by elution with a mixed solvent of chloroform and ethyl acetate (1:2 (v/v)). Thus 60 mg of 7-ethoxycarbonylmethyl-1,4,5,7-tetraazabicyclo[4.3.0]nonan-5-en-3,8-dione was obtained.

Provenance & Evidence