HCID 54196075, compound → HCID 54458996, compound

Participants

Reaction Steps

A solution of (S)-N-[2-(3,4-dichlorophenyl)-4-[4-methoxycarbonyl-4-(2-oxopiperidino)piperidino]butyl]-N-methylbenzamide (0.65 g) in tetrahydrofuran (15 mL) and 1.0N sodium hydroxide (15.5 mL) was heated at reflux overnight. After the tetrahydrofuran was distilled off, the resulting aqueous mixture was adjusted to a pH of 5.5-6.0 and extracted several times with dichloromethane. The organic extracts were dried and evaporated. The crude product was suspended in ether and filtered to give the title compound as a white solid (0.25 g); MS: m/z=560(M+1).

Provenance & Evidence