反应详情

This compound was prepared from isophorone (0.168 g, 1.22 mmol) in the manner previously described for enone 13, affording 0.342 g (60%) of the alkylation product (Rf 0.40, 2:1 hexanes/ethyl acetate) as a colorless, oily solid. 1H NMR (400 MHz, CDCl3) δ0.20 and 0.22 [2s, 2×3H, Si(CH3)2 ], 0.99 [s, 9H, SiC(CH3)3 ], 1.00 and 1.02 (2s, 2×3H, geminal-CH3 's),b 1.91 (s, 3H, 3-CH3), 2.18 and 2.28 (ABq, 2H), 2.42 (dd, 1H), 2.82 (dd, 2H), 3.70 (s, 3H, OCH3), 5.82 (sl d, 1H, 2-H), 6.71 (s, 1H, 6'-H), 6.92 ppm (s, 1H, 3'-H).